Wednesday, February 13, 2008

Could New Acne Treatment Cause Cancer?

My mother always says "look beneath the skin." Great advice from a child psychologist turned stay-at-home mom for evaluating relationships, but keen advice for evaluating well-respected journalism as well.

Browsing Yahoo Health, an article from Reuters caught my eye. "Drug Combo treats severe acne in women: study." Knowing the emotional turmoil those tiny spots can inflict on the composure of otherwise self-confident women, I rapidly clicked, and even more quickly became alarmed.

This study, published in the January 2008 Journal of the American Academy of Dermatology, cites the combination of the birth control pill Yasmin(r) and spironolactone (a diuretic) as a safe and effective treatment for acne. In this study, recipients had an 85 percent chance of either being free from their acne or having excellent improvement. And complications were low. There was no significant weight gain or menstrual cycle irregularites and no problems with elevated potassium levels.

But, what about the long run? Most of these women are young!

We know that oral contraceptives, such as Yasmin, are associated with a small increase in the risk of pre-menopausal breast cancer. How small? In the worst case scenario in the studies, using these for four years before the birth of a first child conferred a relative risk of 1.4. Simply said, if we consider the current risk of breast cancer to be one in seven women (some may argue one in eight or nine), this risk would now be one in five. This risk can often be justified. Going through pregnancy and delivery could definitely be considered riskier. But acne?

And then add in spironolactone. This is a great drug in certain conditions. It can help with fluid retention in those with heart failure and cirrhosis, and be a life saver for those with a condition called primary aldosteronism. Yet, as with many potentially life-saving treatments, that treatment can come at a cost. Spironolactone is listed in California's Proposition 65 under chemicals associated with a risk of cancer.

Shocking - but not really. Looking back at the treatment of acne over the years, we laugh at our ignorance as we raised cancer risk while treating a cosmetic nuisance. First it was X-rays, now known to increase the risk of thyroid cancer. Then it was sun (UV ) exposure. Will we look back in thirty years and question why we considered a combination of a known and a probable carcinogen an acceptable treatment for something only skin deep?

Myself - I plan on listening to my mother's advice. "Look beneath the skin." With the alarming incidence of breast cancer in our country, and one in three women expected to develop some form of cancer in addition to skin cancer, I think I'll opt for safer alternatives.

And for my kids it serves as an internet lesson. Unlike the TV ads as of late portraying the wonderful advantages of a multitude of meds, a laundry list of potential problems did not follow this article, nor was I able to find a direct way to contact anyone to discuss our concerns.

Get extensive information on cancer prevention by reading "Avoiding Cancer One Day At A Time: Practical Advice for Preventing Cancer" to learn more.